Investigation of BDNF and CGRP gene variants in migraine

Skorobogatykh, K.; Kondratieva, N.S.; Azimova, J.; Sergeev, A.; Fokina, N.M.; Kokaeva, Z.G.; Tabeeva, G.R.; Klimov, E.A.

Авторы: Skorobogatykh K., Kondratieva N.S., Azimova J., Sergeev A., Fokina N.M., Kokaeva Z.G., Tabeeva G.R., Klimov E.A.
Сборник: Abstracts for IHC2015
Серия: Cephalalgia: an international journal of headache
Том: 35
Год издания: 2015
Издательство: SAGE Publications
Местоположение издательства: United States
Первая страница: 267
Последняя страница: 267
DOI: 10.1177/0333102415581304
Аннотация: Objectives: Migraine pathophysiology involves several pathways. A number of observations have suggested that brain-derived neurotrophic factor (BDNF) and the calcitonin gene-related peptide gene (CGRP) play a role in migraine pathophysiology. Our aim was to explore a role of BDNF single nucleotide polymorphism (SNP) rs2049046 A/Tand CGRP SNP rs1553005 C/G in migraine susceptibility and to find possible interaction between them in Russian population. Method: 144 migraine patients (102 episodic migraine (EM) of which 84 migraine without aura (MO), 18 migraine with aura (MA) and 42 with chronic migraine (CM), ICHDIII), and 202 unscreened volunteers as the controls (all live in Moscow). SNPs were genotyped by PCR-RFPL technique using GenePakTM PCR Core (Isogen Lab Ltd.) and oligos synthesized by DNA Synthesis, LLC. Reactions were performed in T100 software (BioRad). Allelic and haplotypic frequencies were estimated. Intergroup comparisons were made using the Mann-Whitney U test. Results: BDNF (rs2049046) T-allele was significantly frequent in migraine than in control group (TT p=0,001, AT p=0,004); in EM group A-allele showed a significant association with MA (AA p=0.038, AT p=0,053); AA-genotype showed significant association with CGRP rs1553005 (with CC-genotype p=0,022, with CG genotype p=0.008). Combination of rs2779249 C-allele and rs2049046 A-allele was significanly higher in migraineurs than in control group (p=0,012). Genotypes frequencies of CGRP (rs2779249) were not different in samples of patients and controls. Conclusion: This study shows that BDNF SNP rs2049046 is associated with migraine susceptibility. Also our data supports the previous studies of interaction between BDNF and CGRP in migraine. WOS:000354559400527 DOI: 10.13140/RG.2.1.4099.8160
Добавил в систему: Климов Евгений Александрович

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