Brain weight and behavioral differences in mouse strains selected for different brain weigh after the selection stopped

Perepelkina, O.; Tarasova, A.; Golibrodo, V.; Lilp, I.; Poletaeva, I.

Авторы: Perepelkina OV, Tarasova AYu, Golibrodo VA, Lilp IG, Poletaeva II
Сборник: 17th Annual Genes, Brain & Behaviour Meeting. Evolutionary Biology Centre. International behavioural and neural genetics society (IBANGS). Uppsala University, Sweden May 19 – 22, 2015
Тезисы
Год издания: 2015
Место издания: IBANGS Uppsala
Первая страница: 62
Последняя страница: 62
Аннотация: The selection of laboratory mice for large and small relative brain weight was performed several times by different investigators. Such selection usually resulted in the appearance of reliable brain weight differences after a few selection generations. Differences in behavior emerged as well. The brain weight differences Large vs Small Brain (LB and SB) lines was about 16-18% of the mean value. In current experiment starting from F22 the selection was discontinued and both lines were bred randomly. The highly significant relative brain weight differences persisted in these generations. Behavioral differences between these strains were also found. In F28 the reaction to 12% i.p. ethanol injections (2.4 mg/kg) was analyzed. Control LB’s explored new box more actively and were less affected by stressful environment than SBs. SB ethanol mice were less anxious in EPM than controls, they started exploration of closed +-maze earlier, moved more actively than saline injected mice.Behavioural changes after ethanol were not so clear in LB mice, although their locomotion level increased. In F32 the effects of i.p. injections of methylglyoxal (MG) were tested and differences between groups were also found.In summ the MG injections in SB mice induced the paradoxical changes which could be described as anxiogenic effects, while practically no changes were noted in LB mice after MG treatment. Laboratory for Physiology and Genetics of Behaviour, Biology Department, Lomonossov Moscow State University. Supported by RFBF, grant n 13-04-00747, Russia. Poster 47. http://www.ibngs.org/assets/documents/program-ibangs-2015.pdf
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