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Atomic-scale lateral heterogeneity and dynamics of two-component lipid bilayers composed of saturated and unsaturated phosphatidylcholinesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Pyrkova D.V., Tarasova N.K., Pyrkov T.V., Krylov N.A., Efremov R.G.
- Журнал: Soft Matter
- Том: 7
- Номер: 6
- Год издания: 2011
- Издательство: Royal Society of Chemistry
- Местоположение издательства: United Kingdom
- Первая страница: 2569
- Последняя страница: 2579
- Аннотация: Studies of lateral heterogeneity in cell membranes are important since they help to understand the physical origin of lipid domains and rafts. The simplest membrane mimics are hydrated bilayers composed of saturated and unsaturated lipids. While their atomic structural details resist easy experimental characterization, important insight can be gained via computer modeling. We present the results of all-atom molecular dynamics simulations for a series of fluid dioleoylphosphatidylcholine (DOPC) and dipalmitoylphosphatidylcholine (DPPC) bilayers. Lateral arrangement of lipids in these systems is not random and reveals small geometrical and hydrophobic clusters on the surface. Being “sharp” inside the bilayer, lateral heterogeneity is much “fuzzy” on the surface. This picture is highly dynamic – lifetimes of clusters are ~1 ns. In the binary system, DPPC acts as an “order-preferring” agent, which efficiently modulates behavior of DOPC. Bilayer properties are tuned in a wide range by the chemical nature and relative content of lipids. The impact that the micro-heterogeneity may have on formation of lateral domains in response to external signals is discussed. Understanding of such effects creates a basis for rational design of artificial membranes with predefined properties.
- Добавил в систему: Ефремов Роман Гербертович