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Selenoproteins that function in cancer prevention and promotionстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.
- Авторы: Hatfield Dolph L., Yoo Min-Hyuk, Carlson Bradley A., Gladyshev Vadim N.
- Журнал: Biochimica et Biophysica Acta - General Subjects
- Том: 1790
- Номер: 11
- Год издания: 2009
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 1541
- Последняя страница: 1545
- DOI: 10.1016/j.bbagen.2009.03.001
- Аннотация: Of the many health benefits attributed to selenium, the one that has received the most attention is its role in cancer prevention. Selenium-containing proteins (selenoproteins) have been shown in recent years to have roles in cancer prevention. However, selenoproteins have diverse functions and their view as antioxidants is oversimplified. Some selenoproteins appear to have a split personality in having roles both in preventing and promoting cancer. The contrasting roles of one selenoprotein, thioredoxin reductase 1, in cancer are discussed in detail, but as also noted, at least one other selenoprotein may also have such a dual function. In addition, we discuss examples of inhibition of cancer development by selenoprotein deficiency in mouse models. These studies highlight the complex nature of selenium in relation to cancer.
- Добавил в систему: Гладышев Вадим Николаевич