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The Krushinsky-Molodkina rat strain: The study of audiogenic epilepsy for 65 yearsстатья
- Авторы: Poletaeva I.I., Surina N.M., Kostina Z.A., Perepelkina O.V., Fedotova I.B.
- Журнал: Epilepsy and Behavior
- Год издания: 2015
- Издательство: Academic Press
- Местоположение издательства: United States
- Аннотация: Abstract The more recent history and main experimental data for the Krushinsky-Molodkina (KM) audiogenic rat strain are presented. The strain selection started in late 1940. Now this strain is inbred, and two new strains are maintained in a laboratory in parallel. These strains originated from KM×Wistar hybrids and were bred (starting from 2000) for no-seizure and intense audiogenic seizure phenotypes, respectively. The experimental evidences of audiogenic seizure physiology were accumulated in parallel with (and usually ahead of) data on other audiogenic-prone strains. The peculiar feature of the KM strain is its vulnerability to brain hemorrhages. Thus, the KM strain is used not only as a genetic model of seizure states, but also as a model of blood flow disturbances in the brain. This article is part of a Special Issue entitled: "Genetic Models-Epilepsy". doi: 10.1016/j.yebeh.2015.04.072. Preprint: http://www.ncbi.nlm.nih.gov/pubmed/26228091 http://www.sciencedirect.com/science/journal/aip/15255050
- Добавил в систему: Лильп Ирина Германовна