Molecular mechanisms of latent inflammation in metabolic syndrome. Possible role of sirtuins and peroxisome proliferator-activated receptor type gamma

Stafeev, I.S.; Menshikov, M.Y.; Tsokolaeva, Z.I.; Shestakova, M.V.; Parfyonova, Y.V.

Авторы: Stafeev I.S., Menshikov M.Y., Tsokolaeva Z.I., Shestakova M.V., Parfyonova Ye V.
Журнал: Biochemistry (Moscow)
Том: 80
Номер: 10
Год издания: 2015
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 1217
Последняя страница: 1226
DOI: 10.1134/S0006297915100028
Аннотация: The problem of metabolic syndrome is one of the most important in medicine today. The main hazard of metabolic syndrome is development of latent inflammation in adipose tissue, which promotes atherosclerosis, nonalcoholic fatty liver disease, myocarditis, and a number of other illnesses. Therefore, understanding of molecular mechanisms of latent inflammation in adipose tissue is very important for treatment of metabolic syndrome. Three main components that arise during hypertrophy and hyperplasia of adipocytes underlie such inflammation: endoplasmic reticulum stress, oxidative stress, and hypoxia. Each of these components mediates activation in different ways of the key factor of inflammation – NFκB. For metabolic syndrome therapy, it is suggested to influence a number of inflammatory signaling components by activating other cell factors to suppress development of inflammation. Such potential factors are peroxisome proliferatoractivated receptors type γ that suppress transcription factor NFκB through direct contact or via kinase of a NFκB inhibitor (IKK), and also the antiinflammatory transcription factor AP1. Other possible targets are type 3 NAD+dependent histone deacetylases (sirtuins). There are mutually antagonistic relationships between NFκB and sirtuin type 1 that prevent development of inflammation in metabolic syndrome. Moreover, sirtuin type 1 inhibits the antiinflammatory transcription factor AP1. Study of the influence of these factors on the relationship between macrophages and adipocytes, macrophages, and adipose tissuederived stromal cells can help to understand mechanisms of signaling and development of latent inflammation in metabolic syndrome.
Добавил в систему: Стафеев Юрий Сергеевич

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