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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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2'-Hydrazine oligonucleotides: synthesis and efficient conjugation with aldehydesтезисы доклада
- Авторы: Zatsepin Timofei S., Stetsenko Dmitry A., Gait Michael J., Oretskaya Tatiana S.
- Сборник: Nucleic acids symposium series
- Том: 49
- Тезисы
- Год издания: 2005
- Издательство: Oxford University Press
- Местоположение издательства: United Kingdom
- Первая страница: 133
- Последняя страница: 134
- DOI: 10.1093/nass/49.1.133
- Аннотация: Oligodeoxyribonucleotides that contain a novel nucleoside, 2'-O-(2-hydrazinoethyl)uridine, were synthesized by sodium cyanoborohydride reduction of hydrazones formed from 2'-aldehyde oligonucleotides and FmocNHNH2 followed by ammonia deprotection. 2'-Hydrazine oligonucleotides were used successfully to obtain a series of conjugates with various aldehydes by hydrazone formation. The method was shown to be suitable for the preparation of oligonucleotide-peptide conjugates.
- Добавил в систему: Зацепин Тимофей Сергеевич