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A Novel Approach to Increase the Stability of Liposomal Containers via In Prep Coating by Poly[N -(2-Hydroxypropyl)Methacrylamide] with Covalently Attached Cholesterol Groupsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 16 мая 2018 г.
- Авторы: Zaborova Olga V., Filippov Sergey K., Chytil Petr, Kováčik Lubomir, Ulbrich Karel, Yaroslavov Alexander A., Etrych Tomaš
- Журнал: Macromolecular Chemistry and Physics
- Том: 219
- Номер: 7
- Год издания: 2018
- Издательство: John Wiley & Sons Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 1700508
- DOI: 10.1002/macp.201700508
- Аннотация: Highly stable liposomes are developed by coating phosphatidylcholine liposomes with amphiphilic N‐(2‐hydroxypropyl)methacrylamide copolymer. Two approaches in the preparation of coated liposomes are employed: the copolymer is added during (“in prep”) or after (“ex post”) the liposome formation. The influence of polymer concentration and coating method is evaluated using the cryogenic transmission electron microscopy, dynamic light scattering, and small‐angle X‐ray scattering techniques. The in prep modification significantly increases, up to four weeks, the stability of liposomes against aggregation and makes the liposomal membrane nonpermeable toward an inorganic salt. Such enhanced longevity is attributed to the different structure of in prep coated liposomal membranes.
- Добавил в систему: Заборова Ольга Владимировна