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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Determination of the enantiomeric purity pemetrexed and levalbuterol on the macrocyclic glycopeptide bonded phaseтезисы доклада
- Авторы: Shapovalova E.N., Fedorova I.A., Priporova A.A., Ananieva I.A., Shpigun O.A.
- Сборник: In book “2th Russian conference on medical chemistry"
- Тезисы
- Год издания: 2015
- Место издания: Novosibirsk, Russia
- Первая страница: 269
- Последняя страница: 269
- Аннотация: Macrocyclic glycopeptides, which are immobilized on the surface of silica, are successfully established as chiral selectors in HPLC for enantioseparation of large range of drugs. These chiral phases have high selectivity due to the presence in their structure of various groups capable to multipoint interaction with shared compounds in polar and nonpolar solvents. The aim of this work was the separation of pemetrexed and albuterol enantiomers on silica gel modified by eremomycin (column Nautilus-E, BioChemMac, Russia) and teicoplanin aglycone (column Chirobiotic TAG, Astec, USA). Pemetrexed is drug that is prescribed for malignant pleural mesothelioma and for non-small cell lung cancer. Active substance of pemetrexed is L-isomer. Active substance of albuterol is R-isomer, so-called levalbuterol, which is used as a bronchodilator.
- Добавил в систему: Ананьева Ирина Алексеевна