Laser-ablated silicon nanoparticles: optical properties and perspectives in optical coherence tomographyстатья
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Дата последнего поиска статьи во внешних источниках: 11 августа 2015 г.
Аннотация:Due to their biocompatibility silicon nanoparticles have high potential in biomedical
applications, especially in optical diagnostics. In this paper we analyze properties of the
silicon nanoparticles formed via laser ablation in water and study the possibility of their
application as contrasting agents in optical coherence tomography (OCT). The nanoparticles
suspension was produced by picosecond laser irradiation of monocrystalline silicon wafers
in water. According to transmission electron microcopy analysis the silicon nanoparticles in
the obtained suspension vary in size from 2 to 200 nm while concentration of the particles
is estimated as 10^13cm^−3. The optical properties of the suspension in the range from 400 to
1000 nm were studied by spectrophotometry measurements revealing a scattering coefficient
of about 0.1 mm^−1 and a scattering anisotropy factor in the range of 0.2–0.4. In OCT
study a system with a central wavelength of 910 nm was employed. Potential of the silicon
nanoparticles as a contrasting agent for OCT is studied in experiments with agarose gel
phantoms. Topical application of the nanoparticles suspension allowed the obtaining of the
contrast of structural features of phantom up to 14 dB in the OCT image.