Mechanical activation effect on structure, physicochemical, and biological properties of potassium orotate/magnesium orotatesстатья
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Аннотация:In the present paper, the possibility of the formation of the tautomeric structure of
potassium orotate and magnesium orotate in the solid state is discussed. Using ball milling, we
have received the orotate samples with the predominant content of hydroxy and dihydroxy
forms. The crystalline and tautomeric structures have been analyzed by XRD, IR, NEXAFS
and XPS spectroscopy. There is a slight difference in the water solubility of the orotate
tautomers, but the physicochemical properties (viscosity and volumetric thermal expansion
coefficients) of tautomers’ water solutions significantly differ. The above differences are
related to variation of hydration area of orotate anions due to the composition of the functional
groups being changed together with the structure of tautomers. The residual differences in the
tautomeric structure of solid orotates formed during the milling process are observed in the
orotate water solutions for 1.5-2.5 hours. The biological activity of the water solution of a
hydroxy form relative to erythrocytes and epithelial cells is higher than that of oxo- and
dihydroxy-form water solution