ИСТИНА

Nanodrugs, developed in the V.N.Orekhovich Research Institute of Biomedical Chemistry (Moscow) from soybean phosphatidylcholine, were characterized via small-angle neutron scattering (SANS) at YuMO spectrometer of the IBR-2 reactor. Five different nanodrugs (phospholipid transport nanosystem, phospholipovit, indolip, doksolip, nanoarbidol) were characterized via SANS at their concentration in heavy water 5%, 10%, 25% and temperatures 20oС and 37oC. All nanodrugs have vesicular morphology. Vesicle radius, size polydispersity, thickness of the vesicle bilayer and internal structure of the bilayer were calculated from SANS curves taking into account the intervesicle interaction at concentration of nanodrugs 25%. Results show that vesicle morphology are stable under temperature and concentration variation. Important, that main vesicle parameters (radius, polydispersity, and bilayer thickness) for 25% concentration (pharmaceutical concentration) are near to the parameters at 5% concentration (more appropriate concentration for SANS). The concept of the critically small vesicle was formulated as vesicle, which internal radius is equal to the bilayer thickness. Our results show that nanodrugs divide on the two families: one based on the phospholipid transport nanosystem and other one based on the phospholipovit. Nanodrugs based on the phospholipid transport nanosystem (phospholipid transport nanosystem and indolip) are small vesicles (radius is three times larger then bilayer thickness). Nanodrugs from phospholipovit family (phospholipovit, doksolip, nanoarbidol) are critically small vesicles. The research was financed by the Russian Scientific Foundation (project № 14-12-00516).