ИСТИНА

Telomerase is a key participant of telomere length maintaining system. Using yeast model system we were able to discover a novel mode of telomere length control by telomerase complex. Further study revealed several features of telomere maintenance by telomeric proteins. Structure of N-terminal domain of telomerase reverse transcriptase and its nucleic acid binding properties determined by NMR will be discussed. In mammals telomerase is activated in cancer. Besides being an essential part of telomerase complex telomerase RNA has other function unrelated to telomerase. The data about unusual function of telomerase RNA will be presented. Telomerase RNA is one of the core components of telomerase enzyme. Defects in telomerase RNA maturation result in diseases with age-related phenotype because of decreased clonogenic potential of stem cells. New aspects of human telomerase RNA processing will be presented. This work was supported by Russian Foundation for Basic Research [17-04-00948 A], [17-04-01692 A], [15-54-74005 EMBL_а]; Russian Science Foundation [16-14-10047]