ИСТИНА

Optical coherence tomography (OCT) gives the opportunity to examine peripapillary retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) in order to evaluate evidence of retrograde trans-synaptic degeneration following acquired post- geniculate visual pathway damage. Seventy two patients with homonymous hemianopia caused by acquired post-geniculate visual pathway lesions were examined. Brain tumors were detected in 55 patients, 5 patients were operated for cortical dysplasia (hemianopsia in these patients appeared after surgery), 11 patients had intracerebral hemorrhages, 1 head trauma. The pathological focus was located in the occipital (22), temporal (23), parietal (5), temporoparieto-occipital (22) lobe. RNFL thickness and GCC measurements were carried out in both eyes of each patients with the RTVue-100 Fourier-domain OCT and Canon 3D OCT-2000. Thinning of the GCC in hemiretina ipsilateral to the postgeniculate lesion were found in 45 patients in both eyes. Seventeen of these 45 patients also showed thinning of the RNFL. Topographic analysis of the RNFL was more difficult than GCC. Topographic correspondence between thinning of the RNFL and postgeniculate lesion was demonstrated in 9 of 17 patients. Thinning of the GCC depended on duration since injury and were more common in patients with hemianopsia acquired more than 6 months ago (p<0,0009). The earliest period of GCC thinning was 3 months after brain damage.