ИСТИНА

Click chemistry, renowned for its high chemical efficiency, finds extensive use in synthesis, with the [3+2] cycloaddition of azides and alkynes (the Huisgen reaction) being a prime example. This reaction provides access to 1,2,3-triazoles, a significant family of heterocyclic compounds with diverse applications. Pure organic triazoles with their biological activity are mainly used in medicine. The properties of these triazoles can be notably enhanced by introducing germyl-containing substituents, leading to promising luminescent, semiconducting, pharmacophoric, and antibacterial characteristics. While our prior research focused on 1,4-disubstituted 1,2,3-triazoles bearing R3Ge- and R2GeR3GeGeR2- groups, the work described here reports on the synthesis and study of their 1,5-disubstituted analogues. The target products were studied using by several methods: NMR spectroscopy, UV/visible spectroscopy, luminescence, X-ray structural analysis, and mass spectrometry. Data on the antitumor, antifungal and antimicrobial properties of these compounds were obtained also.