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Functioning of brain and liver mitochondria of rats with experimental audiogenic epilepsy, characterized by the development of oxidative stress. доклад на конференции
- Авторы: Venediktova N.I., Gorbacheva O.S., Belosludtseva N.V., Poletaeva I.I., 1 Mironova G.D., Fedotova I.B.
- Международная Конференция (Конгресс) : The 19th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants
- Даты проведения конференции: 26-27 июня 2017
- Дата доклада: 26 июня 2017
- Тип доклада: Устный
- Докладчик: 1 Mironova G.D.
- Место проведения: University Pierre & Marie Curie, Paris., France
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Аннотация доклада:
Epileptic seizures were studied on audiogenic model of epilepsy of the rats of KrushinskyMolodkina stain (KM) (audiogenic epilepsy). Here we investigated ionic, energetic and oxidative exchange in the brain and liver mitochondria of KM rats. Results: We found that the efficiency of АТР synthesis in the KM rat mitochondria was 10% lower. In KM rats, the concentration of the oxidative stress marker malondialdehyde in mitochondria of the brain (but not liver) was 2-fold higher than that in the control (Wistar) rats. The rate of H2O2 generation in brain mitochondria of КМ rats was 2-fold higher than in the control animals when using NAD-dependent substrates. This difference was less pronounced in liver mitochondria. In KM rats, the activity of mitochondrial ATP-dependent potassium channel was lower than in control rats. The mitochondrial permeability transition pore is easier to trigger in mitochondria of KM rats compared to Wistar rats. Conclusion: The possible ways of correction of the epilepsy seizures are discussed.
- Доклад на конференции выполнен в рамках проекта (проектов):
- Добавил в систему: Федотова Ирина Борисовна