ИСТИНА

Bisphosphonates are of great interest from the point of view of pharmacology. The most famous representatives of the bisphosphonate group - 1-hydroxy-1,1-diphosphonic acids are widely used in medical practice for the treatment of bone diseases. Modification of humic substances by a bisphosphonic group in order to increase their chelating properties is of interest. The introduction of the 1-hydroxy-1,1-bis(phosphonic) group requires a practical and effective method suitable for working with multifunctional substrates such as humic substances. This is a method based on the reaction of tris(trimethylsilyl)phosphite with carboxylic acid chlorohydrides [1]. In the synthesis was used gallic acid - low molecular weight compound which modeling humic substances.