ИСТИНА

This work presents the synthesis of organic donor-acceptor (D-A) molecules based on triphenylamine (TPA) with various donor and acceptor moieties. The relationship between their molecular structure and properties was investigated to optimize their effectiveness in phototherapy and improve the specificity of their effects on cancer cells. Additionally, aqueous dispersions of nanoparticles 50–300 nm in size based on these compounds were prepared and studied with and without amphiphilic polymer matrices. The study demonstrated the potential of the acquired materials for cancer photodynamic therapy due to their high toxicity towards cancer cells (IC50<0.02 mmol and PI>50), generation of reactive oxygen species (ROS), effective light absorption, and photoluminescence in the red spectral range.