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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Biological Behavior of 188Re-Sn Suspension as a Promising Radiopharmaceutical for Radiosynovectomyдоклад на конференции
- Авторы: Klementyeva O.E., Malysheva A.O., Kodina G.E., Taratonenkova N.A., Zhukova M.V., Makarova K.E.
- Международная Конференция (Конгресс) : European Association of Nuclear Medicine 2013
- Даты проведения конференции: 19-23 октября 2013
- Дата доклада: 20 октября 2013
- Тип доклада: Стендовый
- Докладчик: не указан
- Место проведения: Лион, France
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Аннотация доклада:
We successfully synthesized 188Re-Sn suspension, this suspension is stable more than 3 days after its preparation. Optimal conditions for effective labeling (> 95%) was found. About 90 % of particles in the synthesized suspension was lower than 9.3 μm. The results of biodistribution studies show that the 188Re-Sn suspension solidly fixed in the knee joint of rats. Within 72 hours after injection 188Re-Sn suspension is not redistributed in animals. Similar results were also obtained in rabbits. The scintigraphic images of the rabbits, at 24 hr and 72 hr post administration, indicate relevant activity only in the knee.
- Добавил в систему: Клементьева Ольга Евгеньевна