ИСТИНА

Active juvenoids, which are environmentally friendly insecticides, were found among terpenylbenzyl compounds. The key stage of synthesis was the copper-mediated reaction between a terpenyl electrophiles such as chlorides, ammonium salts, carbonate and benzyl Grignard reagents in the presence of copper salts This kind of coupling reactions involves the formation of an organocopper intermediate from a transmetalation reaction. An important issue in this reaction is the control of regiochemistry, i.e., whether the leaving group is displaced - or - by the organometallic reagent. Depending on the reaction conditions and the reagents used, we were able to achieve a high -regioselectivity of the reaction (94-98%).