ИСТИНА

Nanoformulations based on complexes of recombinant human enzyme SOD1 with methoxy-poly(ethyleneglycol)-poly(L-lysine)50 block copolymer cross-linked by 3,3’-dithiobis(sulfosuccinimidylpropionate), as well as nanoformulations based on double layer complexes of SOD1 with protamine and block copolymer of methoxy-poly(ethylene glycol)-block-poly(L-glutamic acid sodium salt) cross-linked with glutaraldehyde were obtained. It was shown in a rabbit model of immunogenic uveitis that the SOD1 containing nanoformulations (nanozymes) can be used as carriers for sustained delivery of SOD1 into ocular tissues for the treatment of inflammation processes in the eye. Topical instillations of the nanozymes in comparison with the instillations of native SOD1 significantly decreased inflammation both in the outer and inner parts of the eye as determined using scores of the clinical manifestations of uveitis, multiple biochemical parameters, and histological analysis.