ИСТИНА

Type 2 diabetes mellitus (DM2) remains one of the most important medical and social problems in most countries of the world. The search for new effective and safe antidiabetic drugs is an urgent task of experimental pharmacology. The decrease neurotrophins’ level, of NGF in particular, at the type 2 diabetes (DM2) have been repeatedly reported. Taking into account the deficiency of the neutrophic factor NGF in DM 2 and the importance of NGF for the pancreatic β-cells functioning, a low-molecular weight NGF mimetic “GK-2” (hexamethylenediamine bis-(N-monosuccinyl-L-glutamyl-L-lysine)) created in V.V. Zakusov Research Institute of Pharmacology was studied in the steptozotocin (STZ) DM2 rats model [4,5]. The purpose of this work is to investigate the effect of GK-2 on insulin resistance in rats with DM2 induced by a high-carbohydrate diet in combination with STZ. Low-molecular weight NGF mimetic GK-2 demonstrated antidiabetic activity and ability to reduce the severity of insulin resistance in rats kept on a high-carbohydrate diet.