ИСТИНА

An industrially scalable technology for the production of bacterial nanocellulose has been developed using a symbiotic culture of Medusomyces gisevii strain Sa-12 on a semi-synthetic glucose medium and hydrolysates of pretreated oat husks. The unique properties of the material consist in extraordinary values of the content of cellulose allomorph Iα (CIα) in the range of 94-100% and the degree of crystallinity (CI) in the range of 88-93%, which is due to the specifics of the use of this producing community. Possible applications of the material include food ingredients, packaging materials with improved functional characteristics, medical devices, diagnostic tools, and drug delivery agents. The potential allergenicity and sensitizing properties of bacterial nanocellulose following a daily oral intake for 35 days were studied using a model antigen - the protein of chicken egg ovalbumin in an in vivo experiment on a model of systemic anaphylaxis in Wistar rats. The results obtained demonstrated in the experimental group a tendency to decrease the mortality of animals caused by the developed reaction of systemic anaphylaxis as a result of the introduction of a resolving dose of the model antigen. Based on the study of the levels of specific circulating IgG and the results of assessing the severity of systemic anaphylaxis reactions, bacterial nanocellulose has no allergenic and sensitizing properties when consumed by the Wistar rats with a diet for 35 days.