ИСТИНА

Recently, researchers have shown a burgeoning research interest in boron nanostructures [1,2] (elemental boron, boron carbide and boron nitride), not only regarding industrial applications but also in the field of biomedicine. Here, we provide an up-to-date summary of the recent advances in boron nanostructures-based nano-medicine. The paper presents a systematic analysis of in vitro and in vivo studies [3]. It has been established that boron nanoparticles are not toxic in the concentration range from several tens to several hundred ppm, and also exhibit an inhibitory effect after neutron irradiation in vitro and in vivo. In a number of experiments, the suppression of the viability of cancer cells reaches 99%, but depends on the conditions of the experiment: the selected cancer cell line/tumor model, concentration and type of boron nanoparticles, neutron fluence.