ИСТИНА

Silicon nanoparticles (NPs) prepared by mechanical grinding of crystalline or porous silicon (PSi) were investigated as sonosensitizers in-vitro. Aqueous suspensions of PSi-based NPs represent porous agglomerates with average sizes from 50 to 200 nm, which consist of Si nanocrystals with minimal sizes of 3÷6 nm. The observed photolu-minescence spectra confirm the nanostructure size of the produced NPs. In-vitro experiments showed that simultaneous action of NPs and ultrasound could result in either the complete destruction of cancer cells, or in their specific damages, which suppressed strongly the cell proliferation activity. This observation demonstrates perspectives of NPs as effective sonosensitizers in order to improve efficiency of the ultrasound therapy of can-cer.