ИСТИНА

The oxidation of monosaccharides is of great scientific and practical importance because compounds containing carboxyl groups are intermediates for several valuable fine chemicals such as pharmaceuticals and biologically active substances. The oxidation reactions are often carried out with expensive and toxic stoichiometric oxidants. This way offers a direct route to the target products; however, the reaction frequently affords non negligible amounts of the side-products and requires additional purification as well as neutralization of the waste. The principles of "green" chemistry are based on the respect for the environment, therefore the task is to develop catalysts which should be easily removed from the reaction medium and reused with high efficiency. It is known that supported transition metal nanoparticles are highly active as heterogeneous catalysts in alcohols and monosaccharides oxidation with molecular oxygen or air. Hypercross-linked polystyrene was chosen for the present study. Such structure combines both micropores and macropores and can be considered for regulated nanoparticle growth. This research focuses on the oxidation process of L-sorbose with synthesis of commercially interesting target product 2-keto-L-gulonic acid (ascorbic acid production).