ИСТИНА

Ferrocene containing compounds are the novel perspective class of biomolecules. The biological activity of ferrocene compounds is closely related to their unique properties: lipophilicity and membrane permeability, low toxicity, planar chirality, redox activity and bulky structure. One compound belonging to the ferrocene series, namely, ocarboxybenzoylferrocene sodium salt has been recommended for use in clinical practice. This drug (“Ferroceron”) is intended for treating diseases caused by iron-deficient anomalies such as anemia of various etiologies, ozena and parodontosis. Early we studied the antitumor activity of against some solid tumor models such as carcinoma 755, melanoma B16 and Lewis lung carcinoma transplanted in mices. It was also found that the mean life-span of tumor-bearing animals with carcinoma 755 as well as with melanoma B16 treated was increased by 30% in comparison with the control. We hypothesized that replacing the phenylene substituents on heterocyclic group will lead to greater antitumor activity.