ИСТИНА

The aim of the work is to develop and characterize molecular systems based on cyclodextrins (CDs), polyethylenimines (PEIs) and mannose – carriers for targeted delivery to alveolar macrophages of drugs for the treatment of a wide range of diseases, including postcovid pneumonia and tuberculosis. Biopharmaceutical properties of drugs loaded into molecular containers can be improved: increased solubility and bioavailability, slowing release in tissues, protection from destruction, concentration of drugs in the target organ, tissues – due to the complexation of fluoroquinolones with cyclodextrin derivatives, as well as their copolymers.