ИСТИНА

In the presented scientific work, the applicability of radical polymerization with a RAFT agent to the polymerization of the monomeric salt of diallyl methylammonium trifluoroacetate (DAMATFA), which proceeds with the efficient transfer of the chain to the monomer, thus largely controlling the process and significantly determining the magnitude of molecular mass and polydispersity, was studied. This scientific field is promising because of the fact that protonated polymers of the diallyl ammonium series exhibit high antimicrobial activity, namely in respect to M. tuberculosis, and therefore are promising for biomedical purposes. One of the important factors necessary for the use of polymers for biomedical purposes is a narrow molecular weight distribution (MMP). Recently, it was shown that the use of the method of reversible chain transfer with fragmentation (the method of OPC or RAFT polymerization) in the radical polymerization of the monomeric salt of diallyl ammonium trifluoroacetate (DAATFA) makes it possible to obtain protonated polymers of PDAAFA with a narrow polydispersity, Mw / Mn = 1.2-1.3. The aim of the work was to study the radical polymerization of DAMATFA monomer in the presence of a RAFT agent under various conditions, to identify the optimal conditions for controlled polymerization and to obtain a PDAMATFA polymer with a rather narrow polydispersity coefficient. To achieve this goal, the following tasks were set: 1. to analyze foreign and domestic literature in the field of controlled living polymerization, including the method of radical polymerization in the presence of a RAFT agent to carry out controlled radical polymerization in order to obtain polymers with low molecular weight and narrow molecular weight distribution; 2. to get acquainted with the methods for producing trifluoroacetate salts of a number of DAA and polymers based on them; synthesize protonated monomers of diallyl ammonium trifluoroacetate (DAATFA) and diallyl methylammonium; 3. to conduct a radical polymerization of the monomer salt of DAMATFA in the presence of a RAFT agent, ethyl xanthogen acetic acid under various polymerization conditions: concentrations of the RAFT agent, monomer and initiator, temperature, polymerization time; 4. to isolate and characterize the obtained polymer products by elemental analysis, 1H and 13C NMR and IR spectroscopy; 5. to analyze the results: establish the ratio of "polymerization conditions - end group of polymers"; to identify the optimal conditions for the preparation of PDAMATFA polymers with a terminal dithiocarbonate group. It is stressed that the research requires hard work and cooperation between biologists and chemical engineers.