ИСТИНА

The preparation of cis-imidazoline derivatives from aromatic aldehydes with ammonia is a convenient and simple synthesis of the precursors of the known inhibitors Mdm2-p53 interaction [1]. Based on molecular docking (Figure 1), it was shown that sulfonamide derivatives of cis- 3,4,5-tris (alkoxyaryl)-imidazolines can bind to the active site of the MDM2 protein. We report about novel series of imidazoline derivatives (synthetized by scheme 1) showed the ability to increase the level of p53, p21 and BAX proteins. Cytotoxicity of compounds in A549 cell lines is in micromole range.