ИСТИНА |
Войти в систему Регистрация |
|
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
We developed a conceptually novel method of β-peptides synthesis based on 1,3-cycloaddition of azomethine ylides [1]. Short well-defined β-proline oligomers with up to 6 monomeric pyrrolidine units were synthesized in racemic and non-racemic forms and characterized by X-ray and CD [1,2]. Some oligomeric derivatives revealed potent antiproliferative activity against hormone-refractory prostate cancer cell line PC-3 [2,3]. References [1] K. V. Kudryavtsev, P. M. Ivantcova, A. V. Churakov, S. Wiedmann, B. Luy, C. Muhle-Goll, N. S. Zefirov, S. Bräse, Angew. Chem. Int. Ed. 2013, 52, 12736-12740. [2] K. V. Kudryavtsev, P. M. Ivantcova, C. Muhle-Goll, A. V. Churakov, M. N. Sokolov, A. V. Dyuba, A. M. Arutyunyan, J. A. K. Howard, C. C. Yu, J. H. Guh, N. S. Zefirov, S. Bräse, Org. Lett. 2015, 17, 6178-6181. [3] K. V. Kudryavtsev, C. C. Yu, P. M. Ivantcova, V. I. Polshakov, A. V. Churakov, S. Bräse, N. S. Zefirov, J. H. Guh, Chem. Asian J. 2015, 10, 383-389.