ИСТИНА

Viruses from the Flavivirus genus are known to be the cause of such dangerous and common diseases as dengue, zika, west nile and yellow fevers, tick-borne encephalitis and some else. Some of these diseases are preventable by vaccination, but no widely approved means of past-anset therapy are available. Our study is aimed to find small molecules to inhibit flavivirus reproduction, focusing on the tick-borne encephalitis virus and particularly its non-structural proteins. Flavivirus NS1 protein structure search, analysis and comparison was performed. From six full-length structures available in Protein Data Bank, four were taken to the further steps of research due to their structural diversity. Binding site analysis revealed cavities in the protein structures that could be targeted by small molecules.