ИСТИНА

Encapsulins are a recently discovered class of semi-permeable spherical nanocompartments found in bacteria and archaea that are implicated in the oxidative stress response and iron biomineralization. We have recently shown the expression of bacterial encapsulins from M. xanthus (~ 32 nm) in mammalian cells for use as genetically encoded nanoparticles for multimodal molecular imaging. In this work, we expand the encapsulin toolbox by introducing larger encapsulins (~40 nm) that prove superior in iron-mineralization enabling multiscale detection by MRI and cryoEM and manipulation in magnetic fields.