ИСТИНА

Terpenes are natural compounds that can be formally considered as isoprene derivatives. Terpenes are present large amounts in coniferous plants, in many essential oils; the most common form is monoterpenes consisting of two isoprene fragments. Their oxygen-containing derivatives are called monoterpenoids. Although monoterpenoids often demonstrate promising biological ac- tivity [1], the role of these compounds in the development of new drugs currently is not great. This is mainly caused by difficulties arising during chemical transformations of monoterpenoids often containing a number of functional groups with similar reactivity and several asymmetric centers. We demonstrated that the use of various types of heterogeneous catalysts (zeolites, modified clays, halloysite nanotubes and so on) allowed one to increase selectivity to target products, including compounds with high anti-Parkinsonian, analgesic or antiviral activity [2-5]. In most cases, very high stereoselectivity was achieved. Another approach to utilize monoterpenoids in chiral compounds synthesis is use of them as a key component of asymmetric catalysts. We are working on the development of new asymmetric catalytic systems based on targeted modification of bispidins with fragments of chiral monoterpenoids both for use in organocatalysis and in metal complex catalysis. References: 1. N.F.Salakhutdinov, K.P.Volcho, O.I.Yarovaya. Pure Appl. Chem., 89, 1105 (2017). 2. M. Stekrova, P. Mäki-Arvela, E. Leino, K.M. Valkaj, K. Eränen, A. Aho, A. Smeds, N. Kumar, K.P. Volcho, N.F. Salakhutdinov, D.Yu. Murzin. Catal. Today, 279, 56 (2017). 3. A.Yu. Sidorenko, A.V. Kravtsova, A. Aho, I. Heinmaa, K.P. Volcho, N.F. Salakhutdinov, V.E. Agabekov, D.Yu. Murzin. ChemCatChem, 10, 3950 (2018). 4. A.Yu. Sidorenko, A.V. Kravtsova, J. Wärnå, A. Aho, I. Heinmaa, I.V. Il’ina, O.V. Ardashov, K.P. Volcho, N.F. Salakhutdinov, D.Yu. Murzin, V.E. Agabekov. Mol. Catal., 453, 139 (2018). 5. A.Yu. Sidorenko, I.V. Il’ina, A.V. Kravtsova, A. Aho, O.V. Ardashov, N.S. Li-Zhulanov, K.P. Volcho, N.F. Salakhutdinov, D.Yu. Murzin, V.E. Agabekov. Mol.Catal., 459, 38 (2018). This work was financially supported by the BRFFR (project Kh19RM-002), RFBR (grant 19-53-04005 Bel_mol_а) and RSF (grant 19-73-20090).