ИСТИНА

The activity of the brain at rest is often suggested to reflect conscious processing of past experience. Here we show that past experience can shape the resting-state networks of a conscious mouse. We modeled post-traumatic stress disorder (PTSD) and imaged c-Fos cellular resting-state networks in PTSD and non-stressed mice. PTSD affected subsequent resting-state activity all over the brain and caused global changes in the resting-state network structure: PTSD network was less clustered and had longer routes than in non-stressed mice. While in naive animals cortical connectivity was high, in PTSD mice thalamus, striatum and amygdala was the most connected. PTSD induction also shifted the main network hub to amygdala. Finally, in fos-Cre-dTomato mice stress-activated neurons were also preferentially active during rest. Thus, we showed that cells previously involved in the consolidation of an impactful memory are predominantly reactivated in the resting state.