ИСТИНА

Physical anthropologists showed that unrelated groups acquire similar somatic and physiological traits under the influence of similar environmental conditions [Alekseeva, 1986]. The purpose of our research is to test whether such convergent similarity manifests itself in the gene pools of populations. Since the traditional diet reflects a complex of biological, technological and cultural aspects of human interaction with the habitat, for the first phase of the project, we have chosen to analyze the genotypes that determine specificities of metabolism of main nutrients. We examined allelic frequencies of the genes APOE rs429358 (lipid metabolism); LCT rs4988235, TREH rs2276064, SI rs781470490 (carbohydrate digestion); VDR BsmI rs1544410 (sensitivity to vitamin D) in the populations of Shors of Southern Siberia and Komi (Zyryans) of North-Eastern Europe. Prior to the 20th century, these geographically distant and unrelated groups had similar subsistence economies in the northern forest ecological zone. The analysis showed a similarity in the distribution of variants of the genes regulating carbohydrate, lipid, and mineral metabolism in the groups of Shors and Komi (Zyryans). Gene pool specificities of these groups and their differences from the agricultural peoples of Eastern, Northern and southern Europe, as well as those living in subtropical regions, are presented in the report. Acknowledgement: supported by RFBR grant 18-09-00487