ИСТИНА

One of the most actively developed methods for the therapy of some types of cancer is HIFU-surgery using high intensity focused ultrasound. For its utilization, HIFU therapy involves extremely high acoustic intensities (~ 0.1-1 kW/cm2), which may cause too negative influence on healthy tissues of a human body. HIFU surgery is limited by the USI selectivity, which is necessary to achieve therapeutic effect relative to vast tumors and individual cells. The effectiveness of USI for medical purposes can be significantly improved by several substances enhancing its action, or sonosensitizers. Sonosensitizers based on porous silicon, which properties of biocompatibility and biodegradability have been proved in various in vitro and in vivo experiments, can be used as such agents. The purpose of the present work is experimental and theoretical study of sonosensitizing properties of aqueous suspensions of mesoporous silicon nanoparticles.