ИСТИНА

Newest results of application of green mechanochemical technology of drug modification are considered. The main approach for pharmacy is based on preparation of solid disperse systems of pharmaceutics substances with different auxiliaries – oligo- and polysaccharide, plant’s saponins, synthetic polymers, amorphous silica substances. After dissolution in water they form supramolecularnanoscale formations such as inclusion complexes, micelles and nanoparticles, which containing drug molecules as «guest-host» types. Noted processes provide sufficiently increase of solubility, bioavailability and pharmacology action (lowering of meaning doses in 2-100 folds) of drug. Examples of drugs investigated are Tranquilizers, non-steroidal, anti-inflammatory. hypertensive, anti-arrhyhtmic, anbiotics, anthelmintic and other drugs.