ИСТИНА

It was demonstrated that NIR duplex probe, specific for functional NF-κB heterodimer: 1) has sufficient sensitivity to functional NF-κB in non-fixed islets and tissues, 2) distinguishes between NF-κB expression in pre-diabetic vs. control pancreas by using FI and FLT techniques. The obtained results are highly relevant to future in vivo translation via NIR imaging of NF-κB activity in the pancreas. The tested NIR duplex probe is not species-specific and has applications in various animal models of inflammatory disease.