ИСТИНА

The aim of the work was to create the inhibitors of HIV replication and other related viruses. A set of new carbamate and phosphonate depot forms of antivirals zidovudine (3’-azido-3’-deoxythymidine, AZT) and lamivudine (L-2’,3’-dideoxy-3’-thiacitidine, 3TC) has been synthesized. In addition, new acyclic phosphonate derivatives of purines containing oximes in the side-chain were designed and synthesized. The antiviral activity of the products in cell cultures infected with HIV, herpes viruses or hepatitis C virus has been studied, as well as cytotoxicity in uninfected cells; pharmacokinetics of the most promising depot forms of nucleosides was studied in the animal models.