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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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In our recent study we have synthesized new acyclic nucleotide analogues with broad antiviral activity: E- and Z- 9-{2-[(phosphonomethyl)oximino]ethyl}adenine containing oxime fragment in the chain. During this synthesis some findings for aminooxycompounds that allowed us to obtain overall yield of 75% were discovered. The final Z and E isomers demonstrated anti-HIV and anti-herpetic activity as well as inhibited a full-length hepatitis C virus replicon.