ИСТИНА

Protein biosynthesis has a major impact on cellular homeostasis. Aging animals are characterized by dysregulation in proteostasis. However, it is mostly unknown to what extent translation mechanisms are involved in this process. To investigate this issue, we applied the methods of ribosome profiling to various organs of mice of different age. Both qualitative and quantitative changes in translatome have been observed, including a decrease in the expression levels of many genes involved in translation itself. Protein synthesis emerges as one of the most important processes in regulation of lifespan. Its manipulation may both decrease and increase lifespan, providing opportunities for novel interventions. A comprehensive analysis of transcription and translation dynamics in aging mice will be presented. The work was supported by the Russian Federation grant №14.W03.31.0012.