ИСТИНА

Recently nanoparticles have got wide application in technology, industry and science. Although the nanotechnology field is growing rapidly, the potential harmful effects of nanomaterials on human’s health or the environment have not yet been identified. It is very essential to figure out possible toxic effect of nanoparticles on biocoenosis and type of mechanism of interaction with live organisms. Understanding mechanism of toxicity nanomaterials might be very helpful for making forecast about safety of further increasing of productivity nano-sized materials. Within our study, we investigate influence of different type of stabilizers on physicochemical properties, stability and behavior of silver nanoparticles. In our experiments, we selected zebra fish embryos as test organisms due to their sensitivity to toxicants and simplicity of experiments for real-time assessments of eco-toxicity. We carried out the experiments on a hydrobionts according to standard procedures (OECD report_236). We observed how change activity of NPs in time and that happened with silver NPs during experimental time. Different mechanisms of coordination nanoparticles with stabilizers provide the variety in stability of obtained colloids and in behavior with respect to diluting by water and test media (standart E3). Contribution of stabilizer and particles themselves in toxicity for Danio rerio were analyzed. Colloids silver solutions demonstrate combined mechanism of toxicity with respect to Danio rerio. Some stabilizers have considerable toxic effect on Danio rerio. Choice of stabilizing agent significantly influences the results of toxicity tests. Therefore, toxic effects of stabilizers must be sufficiently evaluated during experiments. By changing the stabilizers, chemists can tremendously vary properties of NPs. The optimal choice provides the balance between applications and toxicity of silver nanoparticles.