Polyelectrolyte Assembling for Protein Microencapsulationстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:We have developed a novel microencapsulation technique based on covering micronized protein-containing aggregates with a polyelectrolyte
multilayer. Here we describe the procedure of the incorporation of pancreatic proteases or ovalbumin into microparticles by layer-by-layer
adsorption of oppositely charged polyelectrolytes (dextran sulfate, chitosan) on a proteinaceous core and give an account of the impact of the
microencapsulation protocol on the protein release parameters. Insoluble protein-polyanion microaggregates were used as templates. Microparticles
varying in the number of cycles of polyelectrolyte adsorption on protein-polyanion aggregates were examined and compared. Polyelectrolyte
microparticles were shown to retain the shape and dimensions of the initial template. The microparticles were stable at pH below 5; at pH close
to the pH of small intestine a protein release started. The higher the number of polyelectrolyte adsorption cycles was, the lower was the protein
release rate. The microparticles obtained seem to be a promising vehicle for oral protein delivery.