New insights on the application of half‐sandwich complexes with metal–iodide bonds for agricultural fungicides

Авторы: Corsini Maddalena, Fabrizi de Biani Fabrizia, Policastro Antonella, Shvydkiy Nikita V., Baini Giulia, Biagi Marco
Журнал: Applied Organometallic Chemistry
Год издания: 2024
Издательство: John Wiley & Sons Inc.
Местоположение издательства: United States
DOI: 10.1002/aoc.7389
Аннотация: Cyclopentadienyl half-sandwich complexes of cobalt and iron with metal–iodide bonds were reported to efficiently inhibit the growth of phytopathogenicfungi. With the aim of investigating the structure/activity relationships, furtherin vitro experiments were carried out. Cyclic voltammetric characterization,chemical stability, and antiradical activity were performed in two solvents:dimethyl sulfoxide and acetone. The iodide ion removal from the complexappears to be the key point of antifungal activity. Moreover, a preliminary cellviability test on human keratinocytes was also assessed in order to verify thenontoxic effect of tested compounds. The cytotoxicity for all the complexes wascomparable with that shown by povidone iodide, a common antifungal agentrecognized as safe (IC50 > 300 mM). Furthermore, the work proposes an additionalroadmap (sequence of experiments) at the initial antifungal activitytests, which improves insight into their mechanism of action.
Добавил в систему: Швыдкий Никита Вячеславович

	ИСТИНА	Войти в систему Регистрация
	Интеллектуальная Система Тематического Исследования НАукометрических данных
	Главная Поиск Статистика О проекте Помощь

ИСТИНА