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Enhanced bone repair by silver-doped magnesium calcium phosphate bone cementsстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Krokhicheva Polina A., Goldberg Margarita A., Fomin Alexander S., Khayrutdinova Dinara R., Antonova Olga S., Baikin Alexander S., Konovalov Anatoliy A., Leonov Aleksander V., Mikheev Ivan V., Merzlyak Ekaterina M., Kirsanova Valentina A., Sviridova Irina K., Sergeeva Natalia S., Barinov Sergey M., Komlev Vladimir S.
- Журнал: Ceramics International
- Год издания: 2023
- Издательство: Pergamon Press Ltd.
- Местоположение издательства: United Kingdom
- DOI: 10.1016/j.ceramint.2023.03.052
- Аннотация: The aim was to create magnesium calcium phosphate bone cements (MCPCs) based on struvite and newberyite phases and having antibacterial properties due to the presence of Ag+ ions. An increase of Ag+ concentration from 0.5% to 1.0% substantially enhanced mechanical properties of the cements [compressive strength reached 41 ± 2 MPa (mean ± SD)] and increased the inhibition zone up to 8 mm in a disk diffusion test against Escherichia coli and Staphylococcus aureus without toxicity to MG-63 cells in vitro. Analyses of the MCPC samples soaked in Kokubo’s simulated body fluid showed the formation of coatings on the cements’ surface, corresponding to a merrillite phase and, after 28 days of the soaking, to a bobierrite phase. Histological examination and micro-CT analysis revealed that the newly developed MCPCs are osteoconductive and biodegradable and may be used as a bone substitute.
- Добавил в систему: Михеев Иван Владимирович