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Changes in Electroencephalogram Indicators in Patients in the Somatogenic Phase of Acute Poisoning with Opioid Receptor Agonistsстатья Исследовательская статья
- Авторы: Mikhailov A.Yu, Berezina I.Yu, Sumsky L.I., Scheidegger Yu M., Goretskaya T.A., Arzumanov Yu L.
- Журнал: Neuroscience and Behavioral Physiology
- Том: 52
- Номер: 8
- Год издания: 2022
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- Первая страница: 1184
- Последняя страница: 1194
- DOI: 10.1007/s11055-023-01346-3
- Аннотация: Objectives. To evaluate electroencephalogram (EEG) parameters using computerized data processing methods to analyze the possible neurophysiological mechanisms underlying changes seen in patients in the somatogenic phase of acute poisoning with opioid receptor agonists. Materials and methods. The study included 31 patients in the somatogenic phase of acute poisoning with opioid receptor agonists with a level of consciousness of 3–15 points on the Glasgow Coma Scale. EEG recordings were made in accordance with the guidelines of the International Federation of Clinical Neurophysiologists. Indicators of brain electrical activity were analyzed and EEG data were processed by computer (spectral analysis, localization of equivalent dipole sources of pathological brain electrical activity, localization of equivalent current density maxima for EEG oscillations in the neocortex). Results and discussion. The EEG of most (65%, n = 20) patients was dominated by δ-range oscillations. Eight patients showed marked EEG changes, with a maximum amplitude of background oscillations of up to 45–55 μV in the absence of an α rhythm (four patients), though oscillations in the α frequency range could also be present in the EEG with an index of no more than 15–20% of the overall duration of the EEG recording (three patients) and, in one case, bilateral bursts of δ range oscillations (amplitude up to 145 μV) generalized in both hemispheres on this background. Gross EEG changes with diffuse slow-wave activity were detected in 12 patients, with dominance of δ-range index and power. The amplitude of the background δ oscillations was in the range 55–170 μV, reaching 200 μV during bilateral bursts. Conclusions. These results suggest that the EEG changes detected in these patients result from dysfunction of generator mechanisms of both the cortical and the arousal structures of the brain, while the slow-wave, predominantly δ activity, recorded here, taking into account the time the recordings were made (the somatogenic phase), may be due to the actions of secondary modifying factors (hypoxia and cerebral edema).
- Добавил в систему: Михайлов Александр Юрьевич