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Switchable targeting of solid tumors by BsCAR T cellsстатья Электронная публикация
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Stepanov Alexey V., Kalinin Roman S., Shipunova Victoria O., Zhang Ding, Xie Jia, Rubtsov Yuri P., Ukrainskaya Valeria M., Schulga Alexey, Konovalova Elena V., Volkov Dmitry V., Yaroshevich Igor A., Moysenovich Anastasiia M., Belogurov Alexey A., Zhang Hongkai, Telegin Georgij B., Chernov Alexandr S., Maschan Mikhail A., Terekhov Stanislav S., Wu Peng, Deyev Sergey M., Lerner Richard A., Gabibov Alexander G., Altman Sidney
- Журнал: Proceedings of the National Academy of Sciences of the United States of America
- Том: 119
- Номер: 46
- Год издания: 2022
- Издательство: National Academy of Sciences
- Местоположение издательства: United States
- Номер статьи: e2210562119
- DOI: 10.1073/pnas.2210562119
- Аннотация: The use of tumor-associated antigens to target solid tumors by chimeric antigen receptor (CAR) T cells remains limited by the lack of tumor-specific antigens required to avoid on-target off-tumor effects. Programmable CAR systems are being developed to achieve more sophisticated tumor recognition and enhance the controllability of CAR T cells. Here, we propose to harness the RNase toxin barnase as a targeting module that provides the cytotoxic effects itself or in combination with CAR T cells. Molecular switches based on the DARPin-barnase proteins and universal barstar-based CAR (BsCAR) were designed and validated in vitro and in vivo. We expect this strategy may be a promising approach for the generation of safe and efficient CAR T cell therapy against solid tumors.
- Добавил в систему: Ярошевич Игорь Александрович