ZnO and TiO2 particles: a study on nanosafety and photoprotection

Авторы: Popov A., Zhao X., Zvyagin A., Lademann J., Roberts M., Sanchez W., Priezzhev A., Myllylä R.
Сборник: Biophotonics: Photonic Solutions for Better Health Care II
Том: 7715
Год издания: 2010
Издательство: SPIE-The International Society for Optical Engineering
Местоположение издательства: Bellingham, WA, United States
Первая страница: 77153G
DOI: 10.1117/12.854561
Аннотация: Nanoparticles of titanium dioxide (TiO2) and zinc oxide (ZnO) are used in sunscreens as protective compounds against UV radiation. We investigate these particles from the viewpoint of nanosafety (penetration into skin in vivo, production of free radicals when UV-irradiated) as well as UV protection. We show that: a) even after multiple applications, the particles remain within stratum corneum (uppermost skin layer); b) the optimal sizes are 62 nm and 45 nm, respectively for TiO2 and ZnO particles for 310-nm light and, correspondingly, 122 and 140 nm - for 400-nm radiation; c) in general, small particles (25 nm in diameter) are more photoactive than the larger ones (400 nm in diameter); however, on the background if porcine skin in vitro this difference is not seen and is substantially surpassed by skin contribution into production of free radicals.
Добавил в систему: Приезжев Александр Васильевич

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