Аннотация:ORGANIZED BIO-INORGANIC NANOSTRUCTURES BASED ON INTERFACIAL DNA COMPLEXES
Gennady B. Khomutova, Maria N. Antipinaa, Mikhail Artemyevb, Dmitry I. Chernichkoa,
Radmir V. Gainutdinovc, Dmitry Kisielb, Vladimir V. Kislovd, Yury A. Koksharova, Anna A. Rakhnyanskayae,
Andrey N. Sergeev-Cherenkova, Alla L. Tolstikhinac
a Faculty of Physics, Moscow State University, 119992 Moscow, Russia
b Institute for Physico-Chemical Problems, Belarussian State University, 220080 Minsk, Belarus
c Institute of Radioengineering and Electronics RAS, 101999 Moscow, Russia
d Department of Chemistry, Moscow State University, 119992 Moscow, Russia
e Institute of Crystallography RAS, 119899 Moscow, Russia
Development of new effective nanofabrication methods with reasonable costs is currently of principal importance for practical advancements in nanoscience and nanotechnology. The synthetic and assembling methods based on interfacial interactions can be useful instrument of molecular nanotechnology for fabrication of new organized low-dimensional nanostructures [1,2]. Due to the unique DNA structure, physicochemical properties, recognition capabilities and synthetic availability of practically any desired nucleotide sequences and lengths DNA molecules are promising building blocks and nano-templates for controllable fabrication of various organized bio-inorganic nanostructures. Recently, we have obtained novel interfacially-assembled DNA/amphiphilic polycation complexes which were used to form new planar nanoscale-organized polymeric and composite nanostructures [3,4].
Here we report on the formation of new nanoscale-organized DNA complexes with highly-luminescent CdSe nanorods (about 3 nm in diameter and 25 nm in lenght) and magnetic nanoparticles (Fe3O4, ~5 nm in diameter). The obtained nanostructures were characterized by atomic force microscopy and transmission electron microscopy techniques. DNA/CdSe nanorods complexes were formed via interactions of cationic colloid CdSe nanorods with preformed immobilized planar complexes of DNA and water-insoluble amphiphilic polycation prepared via DNA binding with mixed Langmuir monolayer composed by amphiphilic polycation and neutral lipid phosphatidylcholine dipalmitoyl (molar ratio 1:1) on the surface of native DNA aqueous solution with low ionic strength (1 mM NaCl) followed by deposition of interfacial DNA complex onto the solid substrates using Langmuir-Blodgett technique [5]. Water-insoluble amphiphilic polycation used in our work was a derivative of poly-4-vinylpyridine (PVP) with 20% cationic cetylpyridinium groups (PVP-20). Linear charge density as well as hydrophilic-hydrophobic balance of quaternized PVP derivatives can be controlled easily by varying the extent of N-alkylation and the nature of alkyl groups. The obtained DNA/CdSe nanorod complexes represent a new class of highly-organized bio-inorganic nanostructures in which nanorods are oriented and organized as collinear monorod strings and bunch structures of about micrometer lenght and tens nanometer in diameter. Anisotropic linear orientation of highly luminescent CdSe nanorods in the complex results in interesting anisotropic optical and electronic properties of that nanostructure [5]. It was found that formation of organized DNA/CdSe nanorod complexes was a time-dependent self-organization process. Organized nanostructures formed by DNA complexes and colloid cationic CdSe nanocrystals (Q-dots) were also formed by similar procedure. Organized planar net-like nanostructures of magnetic nanoparticles were obtained via interaction of cationic colloid magnetite nanoparticles with preformed immobilized planar complexes of DNA and PVP-20. The data obtained give an insight into mechanisms of nanoscale structure formation and transformation processes in DNA complexes, and demonstrate the potential of methods based on self-organization principles and ligand exchange and substitution reactions in interfacially-formed DNA complexes for cost-effective fabrication of new nanoscale-organized hybrid bio-inorganic nanostructures with advanced properties.
1. G.B. Khomutov, Adv. Colloid Interface Sci., 111 (2004) 79.
2. G.B. Khomutov, M.N. Antipina, A.N. Sergeev Cherenkov, A.A. Rakhnyanskaya, M. Artemyev, D. Kisiel, R.V. Gainutdinov, A.L. Tolstikhina, V.V. Kislov, Int. J. Nanosci., 3 (2004) 65.
3. G.B. Khomutov, M.N. Antipina, A.N. Sergeev-Cherenkov, T.V. Yurova, A.A. Rakhnyanskaya, V.V. Kislov, R.V. Gainutdinov, A.L. Tolstikhina, Mat. Sci. Eng. C., 23 (2003) 903.
4. M.N. Antipina, R.V. Gainutdinov, A.A. Rachnyanskaya, A.L. Tolstikhina, T.V. Yurova, G.B. Khomutov, Surf. Sci., 532–535 (2003) 1025.
5. M. Artemyev, D. Kisiel, S. Abmiotko, M.N. Antipina, G.B. Khomutov, V.V. Kislov, A.A. Rakhnyanskaya, Self-Organized, Highly Luminescent CdSe Nanorod-DNA Complexes, J. Am. Chem. Soc., 126 (2004) 10594.